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Scientists discover better drugs for sleep problems
 

Washington, April 9: The discovery of cellular switches in the bio-clock that tells the body when to sleep and metabolise food may lead to new drugs to treat sleep problems and metabolic disorders, including diabetes. Scientists at the Salk Institute for Biological Studies, led by Ronald M. Evans, professor in its Gene Expression Lab, showed that two cellular switches found on the nucleus of mouse cells, known as REV-ERBa and REV-ERBß, are essential for maintaining normal sleeping and eating cycles and for metabolism of nutrients from food. The findings describe a powerful link between circadian rhythms and metabolism and suggest a new avenue for treating disorders of both systems, including jet lag, sleep disorders, obesity and diabetes, the journal Nature reported. “This fundamentally changes our knowledge about the workings of the circadian clock and how it orchestrates our sleep-wake cycles, when we eat and even the times our bodies metabolize nutrients,” said Evans, according to a university statement. “Nuclear (pertaining to nucleus) receptors can be targeted with drugs, which suggests we might be able to target REV-ERBa and ß to treat disorders of sleep and metabolism,” added Evans. Nurses, emergency personnel and others who work shifts that alter the normal 24-hour cycle of waking and sleeping are at much higher risk for a number of diseases, including metabolic disorders such as diabetes. In mammals, the circadian timing system is orchestrated by a central clock in the brain and subsidiary clocks in most other organs. The master clock in the brain is set by light and determines the overall diurnal or nocturnal preference of an animal, including sleep-wake cycles and feeding behaviour. (IANS)

       
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Dibrugarh
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23.6oC
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Imphal
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Rain/thundershowers would occur at many places over Arunachal Pradesh, Assam, Meghalaya, Nagaland, Manipur, Mizoram & Tripura.
 Arunachal News
NSTFDC inks MoU with State
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 Meghalaya News
Ardent set for rally on September 19
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Majaw threatens to file defamation suit against ex JHADC CEM
EC to renew trading license of Maheshwari Mining Pvt Ltd
 Northeast News
CPI–M candidate wins Tripura seat with record margin
RN Chamling wins Sikkim by–poll
High Court orders giving compensation
Informer beaten up
 Cachar News
Congress faces humiliating defeat in Silchar
Gautom Roy spoils the prospect of Arun Dutta Mazumdar
Congress maintains winning spree in Lakhipur
 National News
The rot that is India’s prison system
Plea for CBI probe into Vadra land deal dismissed
Gender sensitisation classes for ’rough’ Delhi Police cops
Government moots CBI probe into Salman Khurshid’s NGO
 International News
Iraqi troops retake villages, US jets pound IS positions
President in Ho Chi Minh City; history, art on show
’Pakistan heading towards civil war’
London’s Muslims call for peace after beheading of Briton by IS
 State-1
Assam by–polls: AIUDF retains Jamunamukh seat
OIL contractual workers to intensify stir
Villagers caught between security forces and NDFB
Book on life and works of Birendra Kumar Bhattacharyya released
 State-2
NFRMU stages protest against FDI in Railways
Awareness meeting on traffic rules
Medical camp for expecting mothers held
 Local Sports
Daoga takes ASEBSC to quarters in Bordoloi Trophy
Assam junior athletics Team announced
Kamaleswar Brahma Memorial Football begins
Assam fight back against HP
 Sports
India boxers look to regain lost pride in Incheon
Upbeat India women take on South Korea
Sania India’s mainstay in Asian Games
In 2004, India players left much to be desired: Zico
 Editorial
Unicode for Assamese
On Scottish Independence
Society and Sree Sree Thakur Anukulchandra’s Teachings
Letters to the Editor
 Op-Ed (Sunday)
Willing to wound and yet afraid to strike
’Modi should share power with states for real success’
Arrival of Lord Biswakarma
 
Assam
 
Assam is a northeastern state of India with its capital at Dispur located in the city of Guwahati.
 
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Nagaland
 
Nagaland is a northeastern state of India with its capital at Kohima. located in the Guwahati city.
 
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Mizoram
 
Mizoram is a northeastern state of India with its capital at Aizwal. located in the Guwahati city.
 
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Meghalaya
 
Meghalaya is a northeastern state of India with its capital at Shillong. located in the Guwahati.
 
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Manipur
 
Manipur is a northeastern state of India with its capital at Imphal.
 
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Tripura
 
Tripura is a northeastern state of India with its capital at Agartala.
 
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Arunachal Pradesh
 
Arunachal Pradesh is a northeastern state of India with its capital at Itanagar.
 
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Sikkim
 
Sikkim is a northeastern state of India with its capital at Gangtok.
 
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