Why Alzheimer’s Affects Women More Than Men

Sentinel Digital Desk

Women Live Longer

One major reason is lifespan. Women tend to live longer than men, and Alzheimer’s risk increases with age. While not the sole factor, longevity contributes significantly to the higher number of cases in women.

Hormonal Changes Play a Role

Hormonal changes, especially during menopause, can increase Alzheimer's risk. The drop in estrogen levels affects brain health, making women more vulnerable to memory loss and cognitive decline.

Genetics Add to the Risk

The APOE4 gene, linked to Alzheimer’s, has a stronger effect in women. Women with this gene variant face a higher risk compared to men, highlighting genetic factors in the disease’s impact on women.

Cognitive Reserve Differences

Women’s brains might start with a higher cognitive reserve, but when decline begins, it may progress faster. This could explain why symptoms appear more severe in women once Alzheimer’s develops.

Social and Stress Factors

Stress and caregiving roles, more common among women, may contribute to the risk. Chronic stress impacts brain health and increases vulnerability to cognitive disorders, further widening the gender gap.