GUWAHATI: Dr Bhubaneswar Borooah Cancer Institute (BBCI), Guwahati organized a two days Workshop on Applications of Fluorescence In-Situ Hybridization (FISH) on 6 and 7 December. Significant improvement in molecular cytogenetics in cancer has significantly contributed to understanding the management of cancer. FISH is a test that “maps” the genetic material of cancer cells, including specific genes or portion of genes. The FISH test can provide additional information to help predict a patient’s outcome and whether the patient is likely to respond to chemotherapy drugs. Various types of genetic abnormalities like translocation, inversion, deletion, and duplication can be detected. In breast cancer Her-2 Neu Oncogene can be detected, the presence of which may require treatment targeted therapy with Trastuzumab. It may also be mentioned here that, Trastuzumab which is very expensive is made available at a highly subsidized price at the BBCI pharmacy.
According to Amal Chandra Kataki, Director of BBCI,” detection of translocation of genes can help oncologists identify some types of leukaemia, lymphoma, and sarcomas. Duplication of genes in breast cancer cells also helps oncologists in optimizing treatment.” One lakh sixty-two thousand new breast cancer patients are detected every year in the country, as per the latest report of Globocan 2018. “At BBCI, approximately 600 hundred breast cancer patients are treated annually. The institute has facility for advanced FISH technology”, further stated Kataki.
Jagannath Dev Sharma, Professor and Head of Pathology at BBCI said that, this workshop will benefit biotechnologists, research scientist, and interested pathologists to upgrade their skill by participating in the hands on training. He also stated that, BBCI has started M.Sc in Cancer Biology in collaboration with Gauhati University from 2018.
Avdhesh Kumar Rai from Department of Molecular Biology and Cancer Research at BBCI and Sunil Vats from DSS Imagetech New Delhi, and Anupam Sarma, Shiraj Ahmed and Lopamudra Kakoti all from Department of Pathology BBCI participated as resource persons. Twenty other participants from Assam and the North East attended the workshop.