Why Alzheimer's Affects Women More?

A study indicated that the pituitary gonadotrophin, follicle-stimulating hormone (FSH), causes Alzheimer's disease. FSH inhibition reduces memory loss in Alzheimer's mice. This could be a potential treatment for Alzheimer's in women and explains why women are disproportionately affected.

To a greater extent than men, women suffer from Alzheimer's disease (AD). Women make up the majority (66 per cent) of those affected by Alzheimer's disease. Avoiding or treating other health issues that are AD risk factors, such as diabetes, heart disease, and depression, and byvfollowing a healthy diet are also great ways for women to lower their chances of developing AD.

The signs of the condition are more common in females. Women provide the majority of care for those with Alzheimer's disease.

The symptoms, neuroimaging findings, and pathology hallmarks of Alzheimer's disease manifest differently in men and women. More study is required to determine the causes of these gender differences in Alzheimer's risk and disease patterns.

These factors contribute to Alzheimer's in women

Age

The main risk factor for developing Alzheimer's is just getting older. Though old age and Alzheimer's disease are connected, women tend to outlive men. Women outlive men. The prevalence rate measures the total number of Alzheimer's patients, while the incidence rate measures new cases. Women's post-diagnosis survival rates are significantly higher than men's. The gender gap in Alzheimer's disease incidence is not well understood.

The KDM6A gene, located in the X chromosome, showed promise as a potential resilience factor in research scheduled for 2020. The findings of this study provide insight into why AD has a more profound impact on females. Age-related cognitive decline is mitigated in women due to their higher KDM6A expression. There is a gender difference in KDM6A, with more present in women. It's possible that women are getting sicker because they're living longer, but it's probably not the whole story. Researchers are looking into possible explanations for why women experience a higher rate of this disease.

Structure and function differences

Alzheimer's patients exhibit beta-amyloid plaques, tau tangles, and neuronal loss. These are Alzheimer's brain features. Female-skewing amyloid and tau genes produce more disease-causing proteins. Defective brain survival factors may predispose women to Alzheimer's.

Alzheimer's patients have microglia-caused neuroinflammation. Neuroinflammation results from toxic Aß, tau proteins, and sick, dying, and dead neurons. Along with immune-related genes, this neuroinflammatory response increases Alzheimer's risk. Women have stronger immune responses than men, and Alzheimer's animal models exhibit increased neuroinflammation.

Microglia contain sex-linked traits, and researchers are trying to determine if these changes contribute to Alzheimer's in women.

Sexuality-based genetic and hormonal risk factors

After chronological age, apolipoprotein E4 (APOE4) is the biggest Alzheimer's risk factor. It mostly affects women. It's also expressed differently between races and ethnicities, and has become a fascinating study path for clinical studies and drug development.

Memory loss, confusion, language or speech issues, and a shortened attention span can take decades with early Alzheimer's. Preclinical Alzheimer's is common at menopause. Scientists claim women who lose oestrogen may develop Alzheimer's disease. Post-menopausal oestrogen reduction is still being explored. Androgens are neuroprotective later in life. They maintain men's brain health and function, reducing disease risk.

A study indicated that the pituitary gonadotrophin, follicle-stimulating hormone (FSH), causes Alzheimer's disease. FSH inhibition reduces memory loss in Alzheimer's mice. This could be a potential treatment for Alzheimer's in women and explains why women are disproportionately affected.

Context complicates studying's results. Most studies can't account for education, work, social activities, eating, and exercise. These may affect Alzheimer's risk along with biological variables.

. Men and women absorb and distribute drugs differently. Improve sex-specific clinical trial and patient reaction analyses. By studying sex-based risk variables and how they may contribute to the disease, doctors can better anticipate Alzheimer's risk in their patients, detect the condition, and create individualised prevention and treatment plans.

Focusing on lifestyle and individualised care can minimise women's Alzheimer's risk. Here are some healthy options:

Low-glycaemic, nutrient-rich diet. Eat vitamin C, D, E, Omega-3 fats, lutein, and zeaxanthin.

Exercise and watch your weight. This boosts brain, sight, immunity, and blood pressure.

Age-appropriate sleep is important. Deep sleep removes waste and toxins from the brain and breaks down Aß plaques in early Alzheimer's.

Consider memory games. Mental agility boosts health and well-being regardless of Alzheimer's.

Throughout adulthood, but especially by middle age, avoid or manage Alzheimer's-risk disorders and conditions. Diabetes, heart disease, concussions, depression, etc.