Osaka, Halep, Rublev advance; Cilic retires

-Medvedev makes strong start to title bid

-Halep wins on grand slam return

-Kyrgios throws in towel in first round loss

-Isner sent packing in first round by Nakashima

-Former champion Stephens overcomes Keys in thriller

-Cilic retires first time in more than 800 matches

-Anderson belts down 49 aces in first-round win

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