Klopp's side, one point behind Premier League leader Manchester City with four games left, can go top of the table if it beats Tottenham at Anfield on Saturday, with City facing Newcastle 24 hours later.
But fifth-placed Spurs are battling to finish in the top four and Reds boss Klopp is concerned about the potential damage that Kane and Son -- with 43 goals between them in all competitions this season -- could do.
"Tottenham have massive quality," he said on Friday. "Especially away from home, they are not too bothered about having the ball all the time, stuff like this. They defend compact and then obviously they have some of the best counter-attacking players in the world.
"Up front they have speed like crazy -- Harry Kane, what a player, and obviously fits in that idea extremely well. There's a blind understanding between them (Kane and Son) so I'd say it's probably the biggest challenge for protection we face for a long time."
Liverpool is on a high after sealing its place in the Champions League final against Real Madrid by beating Villarreal this week. Agencies