President Joe Biden declared the catastrophic weather pattern to be "one of the biggest tornado outbreaks in US history," promising to "give whatever is required" to those in need.
"I guarantee you, whatever is needed, the federal government will deliver it," Biden said Americans at a White House press conference on Saturday. His "heart hurts" for everyone who have been impacted by the calamity, particularly the rescue personnel, he said.
"This is the United States of America, and our folks have been severely, badly injured, and they're scared to death right now," Mr Biden told the country. "All we have to do now is keep at it, maintain concentrated, and this will be the centre of my attention until we finish." Governor Andy Beshear of Kentucky declared earlier that it was "the worst tornado system to ever sweep through Kentucky."
He stated, " "We were very convinced we'd lose over 50 Kentuckians earlier this morning about 5 a.m. I'm very sure that figure is north of 70, and it could even top 100 before the day is done." Four tornadoes ripped across the state, according to Mr. Beshear, with the main tornado travelling more than 227 miles (365 kilometres) across the state. Mayfield, he added, had been destroyed by a roof collapse at a candle business, which resulted in "mass fatalities." He went on to say that about 60,000 individuals had been left without electricity.
Mr. Beshear also stated that a state of emergency had been established. "This has been one of Kentucky's worst evenings in history," he remarked.
"The devastation is more greater now that we have first light," he stated during a press conference on Saturday morning.
"However, everyone in the tornado's path, which touched down and stayed down for nearly 227 miles, has been seriously and profoundly damaged." More deaths were verified in other states, including six individuals killed when the roof of an Amazon warehouse crumbled. At least six people were killed at an Amazon warehouse in Edwardsville, Illinois, when a wall the length of a football field fell, along with the roof above it. A total of 100 rescue vehicles were dispatched to the facility, which is located about 25 miles east of St Louis.
According to fire chief James Whiteford, at least 45 Amazon employees were rescued from the debris of the 500,000-square-foot warehouse. In reaction to the event, Amazon CEO Jeff Bezos issued a comment on Twitter.
"The news out of Edwardsville is heartbreaking. We're devastated by the death of our comrades there, and our hearts go out to their families and loved ones "he stated
"Everyone in Edwardsville should know that the Amazon team is dedicated to helping them and will be there for them throughout this difficult time. We want to express our heartfelt thanks to all of the heroic first responders who have worked diligently on the scene."
When a tornado struck the Monette Manor nursing home in northern Arkansas, at least one person died and numerous more were wounded. According to Craighead County Judge Marvin Day, about 20 individuals were trapped inside the structure when it fell.
He stated that five people got critical injuries and a few more had minor ones. The facility contains 86 beds.
Mr. Day also said that another nursing facility in Truman, some 20 miles (32 kilometres) distant, was substantially damaged, but that no one was hurt. Because the building was hazardous, the inhabitants were evacuated.
As according Lieutenant Chuck Brown of the Mississippi County Sheriff's Office, another person was murdered in Leachville when a tornado wrecked a Dollar General Store and ripped apart the city's downtown. According to Dean Flener, a spokesperson for the Tennessee Emergency Management Agency, two storm-related deaths have been recorded in Lake County, in Tennessee's northwestern region.
In neighbouring Obion County, a third fatality was recorded.
Buildings in the Missouri villages of Defiance and New Melle fell, killing one person and injuring two more.