The All India Institute of Medical Sciences (AIIMS), Guwahati, becoming functional at Changsari marks a new milestone in medical research, patient care, and medical education in the Northeast region. Apart from cutting down the out-of-pocket expenditures of a significant number of patients in the region, this institution of national importance will set a new benchmark for research and teaching in undergraduate and postgraduate medical education for other medical colleges and medical research institutes. Affordable and quality tertiary-level care at this premier institute will also attract medical tourists from other regions as well as from different countries. The expeditious completion of the remaining construction work will be critical to AIIMS, Guwahati, functioning at its full capacity. About 85% of the construction work has been completed over the past nearly six years since Prime Minister Narendra Modi laid the foundation stone in 2017. The AIIMS authorities hope to become fully functional with a 750-bed capacity, with an inaugural capacity of 150 beds. The availability of specialists and super-specialists is a key determinant in making it fully functional with the target bed capacity. About 314 of the total 1115 sanctioned faculty positions lie vacant in AIIMS. This is a ground reality that the new AIIMS cannot ignore and must take measures to prevent in the initial years. Apart from the completion of the remaining 15% of construction work, prioritising the recruitment of doctors, nurses, and other human resources during this period should also get equal attention to achieve the end objectives. Cancer and trauma care being two focus areas for AIIMS, the institute can be expected to come up with pathbreaking research into the high prevalence of cancer in the region and offer better solutions to address and mitigate the problem. The All India Institute of Medical Sciences Act, 1956, envisages developing patterns of teaching in undergraduate and postgraduate medical education in all its branches so as to demonstrate a high standard of medical education to all medical colleges and other allied institutions in India; bringing together in one place educational facilities of the highest order for the training of personnel in all important branches of health activity; and achieving self-sufficiency in postgraduate medical education. Other medical colleges in the region raising their standard to that of the AIIMS as envisaged in the Act deserve the focused attention of the states in the region so that a larger population can be benefitted and the burden of providing quality tertiary care is not put only on the premier institute. Allowing such a situation to prevail will result in a heavy rush of patients from all over the region, and waiting times for patients will increase beyond the facility’s capacity. States in the region’s increasing budgetary allocation for medical education and healthcare will be crucial to achieving such goals. The Parliamentary Committee on Estimates expressed the view in one of its reports that “when all AIIMS are governed through the same enactment, namely the amended AIIMS Act, there should be similarity in terms of delegated financial and administrative powers for procurement of equipment and in terms of having specialties and super specialties in all AIIMS so that new AIIMS could also bring themselves on par with AIIMS, New Delhi.” The report mentions that the Ministry of Health has plans to set up AIIMS in each state in a phased manner and that they have received requests from Karnataka, Kerala, Goa, Tripura, Sikkim, Mizoram, and Manipur. It notes that the Ministry is statedly not actively considering any other AIIMS in the region apart from AIIMS Guwahati, keeping in view the cost-benefit analysis. The committee insists that only an AIIMS in the region can be sufficiently accessible and sufficient to all residents of the NE States for specialty and superspecialty treatments and recommends in the report that the setting up of AIIMS or upgrading existing institutes to AIIMS-like institutes in other states should also be considered on a priority basis. The addition of three new medical colleges, one each at Nalbari, Kokrajhar, and Nagaon, has increased the total annual intake of MBBS students in the state to 1500. This will go a long way towards further improving the doctor-patient ratio. A fully functional AIIMS in the state is expected to inspire more students in the region aspiring for quality medical education to strive for cracking national level entrance examinations to get admission into AIIMS. The report of the parliamentary panel has brought to the fore multiple issues that have been encountered by the new AIIMS. The Ministry of Health taking note and taking steps to address those will also be beneficial for the AIIMS Guwahati to overcome similar challenges from the very beginning. States in the Northeast are important stakeholders in facilitating AIIMS Guwahati to become fully functional and undertaking research projects that are important in meeting special requirements for the healthcare needs of the people in the region.